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Product Name
Mouse IL-34 (His Tag) recombinant protein
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Description
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
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Protein name
Interleukin-34
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Protein short names
AI593503; 2010004A03RIK; IL34; C16ORF77; MGC34647; IL-34
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Uniprot ID
Q8R1R4
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Gene Name
Il34
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Pro 235) of mouse mIL34 (NP_001128572.1) precursor was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse mIL34 consists of 226 amino acids and has a predicted molecular mass of 26 kDa. Due to glycosylation, rm IL34 migrates as several bands with the MW of approximately 38 kDa or higher in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Activity
1. Measured by its ability to bind biotinylated recombinant mouse CSF1R in a functional ELISA.
2. Measured in a cell proliferation assay using M-NFS60 mouse myeloid cells. The ED50 for this effect is typically 10-50 ng/mL. -
Validations
Mouse IL-34 Protein (His Tag) SDS-PAGE
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