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Product Name
Human IL-17RD (His Tag) recombinant protein
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Description
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons (By similarity).
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Protein name
Interleukin-17 receptor D
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Protein short names
IL17RD; DKFZP434N1928; FLJ35755; 2810004A10RIK; SEF-S; MGC133309; IL-17RD; MGC118454; AI428510; IL17RLM; HH18; SEF
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Uniprot ID
Q8NFM7
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Gene Name
IL17RD; IL17RLM; SEF; UNQ6115/PRO20026
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of human IL17RD (NP_060033.3) precursor (Met 1-Arg 299) was expressed with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human IL17RD comprises 294 amino acids with a predicted molecular mass of 33.5 kDa. As a result of glycosylation, the apparent molecular mass of rhIL17RD is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human IL17RD Protein (His Tag) SDS-PAGE
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