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Mouse IL12RB2 (His Tag) recombinant protein

Cat.#: 502566

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Product Information

  • Product Name
    Mouse IL12RB2 (His Tag) recombinant protein
  • Documents
  • Description
    Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3.
  • Protein name
    Interleukin-12 receptor subunit beta-2
  • Protein short names
    IL12RB2; A930027I18RIK; IFNM; RP11-102M16.1; IL-12RB2
  • Uniprot ID
    P97378
  • Gene Name
    Il12rb2
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse IL12RB2 (NP_032380.1) extracellular domain (Met 1-Asn 637) was fused with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The secreted recombinant mouse IL12RB2 consists of 625 amino acids and has a predicted molecular mass of 70 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmIL12RB2 is approximately 120-130 kDa due to glycosylation.
  • Purity
    > 97 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to bind Mouse IL12A & IL12B Heterodimer Protein (Cat:CT023-M0802H) in a functional ELISA.
    Immobilized mouse IL12RB2-His at 10 μg/ml (100 μl/well) can bind Mouse IL12A & IL12B Heterodimer Protein (Cat:CT024-M0208H). The EC50 of Mouse IL12A & IL12B Heterodimer Protein (Cat:CT024-M0208H) is 50.2-117.2 ng/ml.
  • Validations

    Mouse IL12RB2 / IL12R-beta 2 Protein (His Tag) SDS-PAGE

    Mouse IL12RB2 / IL12R-beta 2 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"