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Product Name
Human IL1RL2/IL1RRP2 (His Tag) recombinant protein
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Description
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
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Protein name
Interleukin-1 receptor-like 2
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Protein short names
IL-36R; IL-1Rrp2; IL1R-rp2
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Uniprot ID
Q9HB29
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Gene Name
IL1RL2; IL1RRP2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IL1RL2 (NP_003845.2) (Met1-Tyr337) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL1RL2 consists 329 amino acids and predicts a molecular mass of 37.6 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Human IL1RL2 / IL-1Rrp2 Protein (His Tag)
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