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Human IL-1RAcP/IL-1R3 (His Tag) recombinant protein

Cat.#: 502554

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Product Information

  • Product Name
    Human IL-1RAcP/IL-1R3 (His Tag) recombinant protein
  • Documents
  • Description
    Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.
  • Protein name
    Interleukin-1 receptor accessory protein
  • Protein short names
    FLJ37788; IL-1RACP; IL1R3; AI255955; 6430709H04RIK; C3ORF13; IL1RAP; AV239853
  • Uniprot ID
    Q9NPH3
  • Gene Name
    IL1RAP; C3orf13; IL1R3
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human IL1R3 (NP_002173.1) extracellular domain (Met 1-Glu 359) was expressed, fused with the a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL1R3 consists of 350 amino acids and has a predicted molecular mass of 40.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhIL1R3 is approximately 50-55 kDa due to glycosylation.
  • Purity
    > 98 % as determined by SDS-PAGE
  • Validations

    Human IL-1RAcP / IL-1R3 Protein (His Tag) SDS-PAGE

    Human IL-1RAcP / IL-1R3 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"