Human IFN omega (His Tag) recombinant protein

Human IFN omega (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I  and type I I, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN α, β, τ, and ω and bind to the type I  IFN receptor, whereas IFN-γ is the only type I I IFN and is specific for the type I I IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 10%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.

Interferon omega-1

IFNW1; OTTHUMP00000021133; IFN-OMEGA 1; INTERFERON OMEGA-1

P05000

IFNW1

Human Cells

A DNA sequence encoding the human IFNW1 (P05000) (Met1-Ser195) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human IFNW1 consists of 185 amino acids and predicts a molecular mass of 21.6 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV).
The ED₅₀ for this effect is typically 2-8 pg/mL.