Human IFN omega (Fc Tag) recombinant protein

Human IFN omega (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I  and type I I, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN ?, ?, ?, and ? and bind to the type I  IFN receptor, whereas IFN-? is the only type I I IFN and is specific for the type I I IFN receptor. Human IFN-?, was identified by three independent groups in 1985 and is structurally related to IFN-? and -?. Both human IFN-? and IFN-? are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 10%) of the total antiviral activity of leukocyte IFN is contributed by IFN-?l. In addition, it was reported that IFN-? could inhibit the growth of human tumors in vivo.

Interferon omega-1

IFNW1; OTTHUMP00000021133; IFN-OMEGA 1; INTERFERON OMEGA-1

P05000

IFNW1

Human Cells

A DNA sequence encoding the human IFN? (NP_002168.1) (Cys 24-Ser 195) was fused with the Fc region of human IgG1 at the N-terminus.

Human

The recombinant human IFN?/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 409 amino acids with a predicted molecular mass of 46.6 kDa. As a result of glycosylation, rh IFN?/Fc monomer migrates as an approximately 50 kDa band in SDS-PAGE under reducing conditions.

> 92 % as determined by SDS-PAGE

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC₅₀ for this effect is 0.03-0.3 ng/mL.