Human IL-29 (His Tag) recombinant protein

Human IL-29 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interleukin-29(IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein which belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand / receptor complex seems to signal through the Jak-STAT pathway.

Interferon lambda-1

IL29; INTERFERON LAMBDA-1; IL-29; IFN-LAMBDA-1; IFNL1

Q8IU54

IFNL1; IL29; ZCYTO21

Human Cells

A DNA sequence encoding the human IL29 (NP_742152.1) (Met 1-Thr 200) was fused with a polyhistidine tag at the C-terminus.

Human

The recombinant human IL29 consists of 192 amino acids and has a predicted molecular mass of 21.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh IL29 is approximately 30-35 kDa due to glycosylation.

> 92 % as determined by SDS-PAGE

Measured in antiviral assays using HepG2 cells infected with vesicular stomatitisvirus (VSV).
The ED₅₀ for this effect is typically 4-20 ng/ml.