Human AIM2 (GST Tag) recombinant protein

Human AIM2 (GST Tag) recombinant protein

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Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Interferon-inducible protein AIM2

PYHIN4; RP11-520H16.3; AIM2; GM1313; IFI210

O14862

AIM2

Baculovirus-Insect Cells

A DNA sequence encoding the human AIM2 (NP_004824.1) (Met 1-Thr 343) was fused with the GST tag at the N-terminus.

Human

The recombinant human AIM2/GST chimera consists of 567 amino acids and predicts a molecular mass of 65.2 kDa as estimated in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

Measured by its ability to inhibit the proliferation of MCF7 human breast adenocarcinoma cells（Karey, K.P. et al. (1988) Cancer Research 48:4083.). The ED₅₀ for this effect is typically 4-7 μg/ml.