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Product Name
Human IFNA5/IFNaG (Fc Tag) recombinant protein
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Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
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Protein name
Interferon alpha-5
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Protein short names
RP23-139P14.29; IFNA5; RP11-380P16.5; IFA5
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Uniprot ID
P01569
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Gene Name
IFNA5
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IFN? G (NP_002160.1) (Leu 22-Glu 189) was fused with the Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IFN? G/Fc chimera is a disulfide-linked homodimer. The reduced monomer comprises 405 amino acids with a predicted molecular mass of 46.3 kDa. As a result of glycosylation, rh IFN? G/Fc monomer migrates as an approximately 48-50 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC50 for this effect is 0.16-0.8 ng/mL.
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Validations
Human IFNA5 / IFNaG / Interferon alpha-G Protein (Fc Tag) SDS-PAGE
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