Integerrimide B peptide

Integerrimide B peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

cyclo(WALLVSP)

cyclo(-Trp-Ala-Leu-Leu-Val-Ser-Pro-)

7

95.69%

C₃₉H₆₀N₈O₉

784.94

Synthetic

Powder

Integerrimide B is a cyclic heptapeptide isolated from the latex of peregrina / spicy jatropha (Jatropha integerrima).
Integerrimide B significantly inhibited neurite outgrowth in neuronal cell culture at 50 uM.
It partially inhibited proliferation of human IPC-298 melanoma cells and migration of human Capan II pancreatic carcinoma cells.
Integerrimide B was inactive in HSV-1, antifungal, and antimalarial assays.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Mongkolvisut W, Sutthivaiyakit S, Leutbecher H, et al. Integerrimides A and B, cyclic heptapeptides from the latex of Jatropha integerrima. J Nat Prod. 2006;69(10):1435-41.

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.