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Product Name
Human IGSF3 (His Tag) recombinant protein
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Description
Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein which belongs to the EWI subfamily of the Ig Superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in Placenta, kidney and lung. EWI-2 is part of a novel Ig subfamily that includes EWI-F (F2alpha receptor regulatory protein (FPRP), CD9P-1 ), EWI-3 (IGSF3), and EWI-101 (CD101). All four members of this Ig subfamily contain a Glu-Trp-Ile (EWI) motif not seen in other Ig proteins. Human IGSF3 shares 92 % aa identity with mouse IGSF3.
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Protein name
Immunoglobulin superfamily member 3
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Protein short names
2810035F16RIK; MGC117164; LCDD; RP4-781D12.1; V8; MKIAA0466; 1700016K10RIK; 4833439O17RIK; EWI-3; IGSF3
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Uniprot ID
O75054
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Gene Name
IGSF3; EWI3; KIAA0466
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human IGSF3 isoform 1 (O75054-1) extracellular domain (Met 1-Ala 1124) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The secreted recombinant human IGSF3 comprises 1116 amino acids and has a calculated molecular mass of 126.6 kDa. The apparent molecular mass of the recombinant protein is approximately 140 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 98 % as determined by SDS-PAGE
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Validations
Human IGSF3 / EWI-3 Protein (His Tag) SDS-PAGE
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