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Product Name
Recombinant IKZF2 protein (His tag)
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Description
Recombinant Human Zinc Finger Protein Helios (IKZF2) Fragment (105-219) is a highly stable and soluble protein fragment designed for structural and biochemical studies. This product offers researchers a reliable tool to investigate the functional domains of Helios, a key transcriptional regulator in the Ikaros family essential for hearing development and T-cell function.
Zinc finger protein Helios, encoded by the IKZF2 gene, functions as a transcriptional regulator critical for the maturation of outer hair cells (OHCs), which is necessary for hearing. It localizes to the nucleus and associates with Ikaros at centromeric heterochromatin in T-cell nuclei, highlighting its role in gene regulation and cellular differentiation. The full-length protein's involvement in these processes underscores its importance in auditory health and immune system function, making it a valuable target for research in developmental biology and immunology.
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Protein name
Zinc finger protein Helios
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Uniprot ID
Q9UKS7
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Gene Name
IKZF2; HELIOS; ZNFN1A2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 105-219 aa (Q9UKS7) were fused with N-terminal 6His tag.
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Sequence
MSKIKHHHHH HGGSIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY CGRSYKQRSS LEEHKERCH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.74 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant IKZF2 protein (His tag) SDS-PAGE
M: Marker; Lane 1: IKZF2; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"