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Product Name
Recombinant IGKC protein (His tag)
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Description
Recombinant Human Immunoglobulin Kappa Constant (IGKC) Fragment (1-107) – a high-purity protein encompassing the complete Ig-like domain, ideal for investigating antibody structure, B-cell receptor signaling, and humoral immune responses in research applications.
The Immunoglobulin Kappa Constant (IGKC) protein represents the constant region of immunoglobulin light chains, which are critical components of antibodies produced by B lymphocytes. In humoral immunity, membrane-bound immunoglobulins act as antigen receptors on B cells, triggering clonal expansion and differentiation into antibody-secreting plasma cells upon antigen binding. Secreted immunoglobulins then mediate effector functions to eliminate antigens. Each antibody's antigen-binding site is formed by variable domains of heavy and light chains, with the constant region (such as IGKC) contributing to antibody stability and function. The full-length protein is localized to the cell membrane or secreted into the extracellular space, playing a
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Protein name
Immunoglobulin kappa constant
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Uniprot ID
P01834
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Gene Name
IGKC
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-107 aa (P01834) were fused with C-terminal 6His tag.
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Sequence
MNHKVRTVAA PSVFIFPPSD EQLKSGTASV VCLLNNFYPR EAKVQWKVDN ALQSGNSQES VTEQDSKDST YSLSSTLTLS KADYEKHKVY ACEVTHQGLS SPVTKSFNRG ECLEHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.42 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant IGKC protein (His tag) SDS-PAGE
M: Marker; Lane 1: IGKC; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"