Mouse IFNGR2 (His Tag) recombinant protein

Mouse IFNGR2 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Interferon gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2. IFNGR2 is a component of the IFNgamma receptor complex along with the IFNgammaR alpha chain (IFNGR1), and is a new Bax suppressor. The C-terminal fragment (cytoplasmic domain) of IFNgammaR2 is expressed in human cancer cell lines of megakaryocytic cancer (DAMI), breast cancer (MDA-MD-468), and prostate cancer (PC3 cells). The Th1 cytokine IFNgamma, acting through its heterodimeric receptors, IFNgammaR1 and IFNgammaR2, in the induction/proliferation of Th1 cells, might suppress the Th2 responses that may underlie atopic asthma. IFNGR2 has always been seen as a key mechanism for shielding T lymphocytes from the antiproliferative effects of the IFNgamma-signal transducer and activator of transcription 1 (STAT1) pathway.

Ifngr2 protein

IFNGT1; IFNGR2; AF-1; IFGR2; IMD28; IFGT

Q63953

Ifngr2; ifngr2; mCG_11456

Human Cells

A DNA sequence encoding the extracellular domain of mouse IFNGR2 (NP_032364.1) (Met 1-Val 243) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse IFNGR2 comprises 234 amino acids and has a calculated molecular mass of 26.7 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 40-45 kDa in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE