• IETP2 peptide

IETP2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319565

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Optional Service: TFA RemovalWhat's this?

Special Price 214.1 USD

Availability: 3 weeks
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Product Information

  • Product Name
    IETP2 peptide
  • Documents
  • Sequence
    H-TFYGGRPKRNNFLRGIRSRGD-OH
  • Three letter code
    H-Thr-Phe-Tyr-Gly-Gly-Arg-Pro-Lys-Arg-Asn-Asn-Phe-Leu-Arg-Gly-Ile-Arg-Ser-Arg-Gly-Asp-OH
  • Length (aa)
    21
  • Peptide Purity (HPLC)
    95.15%
  • Molecular Formula
    C107H171N39O29
  • Molecular Weight
    2467.73
  • Source
    Synthetic
  • Additional Information
    IETP2 is a peptide identified for its potential in targeting and delivering compounds across the blood-labyrinth barrier (BLB), which is a significant obstacle in treating inner ear disorders. The peptide has shown affinity for the low-density lipoprotein receptor-related protein 1 (LRP1), a receptor expressed on the BLB. IETP2's ability to bind to LRP1 facilitates its transport into the inner ear, offering a promising strategy for enhancing drug delivery to this region. This targeted delivery approach could be crucial for the treatment of various inner ear disorders.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Shi X, Wang Z, Ren W, Chen L, Xu C, Li M, Fan S, Xu Y, Chen M, Zheng F, Zhang W, Zhou X, Zhang Y, Qiu S, Wu L, Zhou P, Lv X, Cui T, Qiao Y, Zhao H, Guo W, Chen W, Li S, Zhong W, Lin J, Yang S. LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB). Signal Transduct Target Ther. 2022 Jun 10;7(1):175. doi: 10.1038/s41392-022-00995-z. PMID: 35680846; PMCID: PMC9184653.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

  • Molar Concentration Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"