Human Iduronate 2-Sulfatase / IDS (His Tag) recombinant protein
Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
Protein short names
IDURONATE 2-SULFATASE 42 KDA CHAIN; SIDS; IDS; MPS2; AW214631; IDURONATE SULFATASE; IDURSULFASE; IDURONATE 2-SULFATASE; RP23-29M4.1; ALPHA-L-IDURONATE SULFATE SULFATASE; IDURONATE 2-SULFATASE 14 KDA CHAIN
A DNA sequence encoding human IDS precursor (NP_000193.1) (Met 1-Pro 550) was expressed with a C-terminal polyhistidine tag.
The secreted recombinant human IDS with the propeptide consists of 536 amino acids after removal of the signal peptide and has a predicted molecular mass of 61 kDa. In SDS-PAGE under reducing conditions, it migrates as several bands with apparent molecular mass between 85-95 KDa due to glycosylation.
> 87 % as determined by SDS-PAGE
Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS).
The specific activity is > 1.0 pmoles/min/μg.
Human Iduronate 2-Sulfatase / IDS Protein (His Tag) SDS-PAGE
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