Hymenochirin-1Pb peptide
Not For Human Use, Lab Use Only.
Cat.#: 300709
Special Price 366.8 USD
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Product Name
Hymenochirin-1Pb peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-LKLSPETKDTLKKVLKGAIKGAIAIASLA-NH2
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Sequence
H-Leu-Lys-Leu-Ser-Pro-Glu-Thr-Lys-Asp-Thr-Leu-Lys-Lys-Val-Leu-Lys-Gly-Ala-Ile-Lys-Gly-Ala-Ile-Ala-Ile-Ala-Ser-Leu-Ala-NH2
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Length (aa)
29
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Peptide Purity (HPLC)
95.15%
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Molecular Formula
C136H246N36O37
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Molecular Weight
2977.61
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Source
Synthetic
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Form
Powder
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Description
Hymenochirin-1Pb is a host-defense peptide isolated from the skin secretions of Merlin's clawed frog (Pseudhymenochirus merlini, Africa).
Hymenochirin-1Pb is structurally similar to hymenochirin-1B from Hymenochirus boettgeri and belongs to the hymenochirin-1P family.
Hymenochirin-1Pb is one of the 13 host-defense peptides identified in the skin secretions of P. merlini, which have antimicrobial activity against bacteria such as Staphylococcus aureus (MIC 5 uM) and Escherichia coli (MIC > 40 uM). The peptides from P. merlini, including Hymenochirin-1Pb, have been characterized for their structural and biological properties, and their potential as antimicrobial agents is being explored. -
Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Conlon JM, Prajeep M, Mechkarska M, et al. Characterization of the host-defense peptides from skin secretions of Merlin's clawed frog Pseudhymenochirus merlini: insights into phylogenetic relationships among the Pipidae. Comp Biochem Physiol Part D Genomics Proteomics. 2013;8(4):352-7.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"