Human VPS36 Recombinant protein (His tag)

Human VPS36 Recombinant protein (His tag)

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Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.

Vacuolar protein-sorting-associated protein 36

C13orf9; EAP45

Q86VN1

VPS36; C13orf9; EAP45; CGI-145

E. coli

A DNA sequence encoding the human VPS36 (NP_057159.2) 1-386 aa was fused with the polyhistidine tag

Human

Not tested.