Human USP19 Recombinant protein (GST tag)

Human USP19 Recombinant protein (GST tag)

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• Material Safety Data Sheets (MSDS)

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. {PubMed:19465887, PubMed:21849505, PubMed:22128162, PubMed:22689415}.

Ubiquitin carboxyl-terminal hydrolase 19

KIAA0891; ZMYND9

O94966

USP19; KIAA0891; ZMYND9

E. coli

A DNA sequence encoding the human USP19 (NP_001186089.1) 304-601 aa was fused with the N-terminal GST tag

Human

Not tested.