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Product Name
Human Ubiquitin specific peptidase 30 / USP30 (SUMO Tag) recombinant protein
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Description
Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnected mitochondria, depending on the activities of the mitochondrial fusion factors mitofusins, without changing the expression levels of the key regulators for mitochondrial dynamics. Mitochondria were rescued from this abnormal phenotype by ectopic expression of USP30 in a manner dependent on its enzymatic activity. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination.
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Protein short names
UBIQUITIN THIOESTERASE 30; DEUBIQUITINATING ENZYME 30; UBIQUITIN SPECIFIC PROTEASE 30; UBIQUITIN THIOLESTERASE 30; 6330590F17RIK; UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 30; D5ERTD483E; AI851327; UB-SPECIFIC PROTEASE 30; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30; USP30
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human USP30 (Thr48-Glu508) was fused with the SUMO tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human USP30 consists of 580 amino acids and predicts a molecular mass of 66.3 KDa. The apparent molecular mass of the protein is approximately 87 KDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human Ubiquitin specific peptidase 30 / USP30 Protein (SUMO Tag) SDS-PAGE
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