Human TRIB2 / TRB2 (His & GST Tag) recombinant protein

Human TRIB2 / TRB2 (His & GST Tag) recombinant protein

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Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).

HCG18830, isoform CRA_a

C5FW; GS3955; AW319517; TRB2; TRIB2; TRB-2; FLJ57420

Q16816

hCG_18830

Baculovirus-Insect Cells

A DNA sequence encoding the human TRIB2 (NP_006204.1) (Met 1-Asn 343) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Human

The recombinant human TRIB2/GST chimera consists of 580 amino acids and predicts a molecular mass of 66.6 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.

> 82 % as determined by SDS-PAGE

Kinase activity untested