Human TRAF6 Recombinant protein (His tag)

Human TRAF6 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. {PubMed:11057907, PubMed:12140561, PubMed:16378096, PubMed:17135271, PubMed:18093978, PubMed:18347055, PubMed:18758450, PubMed:19465916, PubMed:19675569, PubMed:19713527, PubMed:8837778}.

TNF receptor-associated factor 6

RNF85

Q9Y4K3

TRAF6; RNF85

E. coli

1-274 aa encoded by NM_004620 was inserted into PET30a vector

Human

Not tested.