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Product Name
Human TP53RK Recombinant protein (His tag)
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Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {, PubMed:11546806}.
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Protein name
TP53-regulating kinase
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Protein short names
C20orf64; PRPK
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Uniprot ID
Q96S44
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Gene Name
TP53RK; C20orf64; PRPK
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human TP53RK (NP_291028.3) 154-253 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TP53RK SDS-PAGE
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