Human TNFSF4 recombinant protein (N-human IgG1-Fc)

Cat.#: 514852

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Product Information

  • Product Name
    Human TNFSF4 recombinant protein (N-human IgG1-Fc)
  • Documents
  • Description
    OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Immune Checkpoint
    Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein short names
    CD134L,CD252,GP34,OX-40L,OX4OL,TXGP1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TNFSF4 (Gln51-Leu183) was expressed with the Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TNFSF4 consists of 412 amino acids and predicts a molecular mass of 46.6 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human OX-40L / TNFSF4 / CD252 Protein 14122

    Human OX-40L / TNFSF4 / CD252 Protein 14122

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"