Human TNFSF4 recombinant protein (N-human IgG1-Fc)

Human TNFSF4 recombinant protein (N-human IgG1-Fc)

• DataSheet
• Material Safety Data Sheets (MSDS)

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.Immune Checkpoint
Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy

CD134L,CD252,GP34,OX-40L,OX4OL,TXGP1

Human Cells

A DNA sequence encoding the human TNFSF4 (Gln51-Leu183) was expressed with the Fc region of human IgG1 at the N-terminus.

Human

The recombinant human TNFSF4 consists of 412 amino acids and predicts a molecular mass of 46.6 kDa.

> 95 % as determined by SDS-PAGE.