• Human TNFSF14 recombinant protein (N-mouse IgG1-Fc)

Human TNFSF14 recombinant protein (N-mouse IgG1-Fc)

Cat.#: 514847

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Product Information

  • Product Name
    Human TNFSF14 recombinant protein (N-mouse IgG1-Fc)
  • Documents
  • Description
    LIGHT, also known as TNFSF14 or CD258, is a newly identified member of the TNF superfamily (TNFSF14) that is expressed by activated T lymphocytes, monocytes, granulocytes, spleen cells, and immature dendritic cells. TNFSF14 / LIGHT / CD258 is a type II transmembrane protein that is known to bind 2 membrane-bound TNFSF signaling receptors: HVEM, which is predominantly expressed by T cells, and lymphotoxin β receptor (LTβR), which is expressed by stromal cells and nonlymphoid hematopoietic cells. TNFSF14 / LIGHT / CD258 also binds to a soluble nonsignaling receptor, decoy receptor 3 (DcR3), which can modulate the function of LIGHT in vivo. TNFSF14 / LIGHT / CD258 can also costimulate T cell responses via HVEM, which is constitutively expressed in most lymphocyte subpopulations, including CD4+ and CD8+ T cells. In addition, TNFSF14 / LIGHT / CD258 has been shown to suppress tumor formation in vivo and to induce tumor cell apoptosis via the up-regulation of intercellular adhesion molecule 1 and an increased lymphocyte adhesion to cancer cells. Thus, TNFSF14 / LIGHT / CD258 is being actively investigated as a possible basis for cancer treatment.Immune Checkpoint
    Immune Checkpoint Proteins
    Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
  • Protein short names
    CD258,HVEML,LIGHT,LTg,TR2
  • Uniprot ID
    AAK26160.1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TNFSF14 (AAK26160.1) (Asp74-Val240) was expressed with the Fc region of mouse IgG1 at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TNFSF14 consists of 403 amino acids and predicts a molecular mass of 44.9 kDa.
  • Purity
    > (86.1+5.7) % as determined by SDS-PAGE.
  • Validations

    Human TNFSF14/LIGHT/CD258 Protein 14125

    Human TNFSF14/LIGHT/CD258 Protein 14125

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"