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Product Name
Human THAP1 Recombinant protein (His tag)
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Description
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {PubMed:12717420, PubMed:17003378, PubMed:20200153}.
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Protein name
THAP domain-containing protein 1
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Uniprot ID
Q9NVV9
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Gene Name
THAP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human THAP1 (NP_060575.1) 1-213 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human THAP1(Full length) SDS-PAGE
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