Human TCTP /TPT1 (His Tag) recombinant protein

Human TCTP /TPT1 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein which has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE +-dependent allergic reactions. In addition, TPT1 has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis. TPT1 production is thought to be controlled at the translational as well as the transcriptional level.

TUMOR PROTEIN; P21; TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN; TRANSLATIONALLY-CONTROLLED 1; TRT; FORTILIN; TRANSLATIONALLY-CONTROLLED 1; P02; TRANSLATIONALLY REGULATED TRANSCRIPT (21 KDA); RP11-290D2.1; TCTP; HRF; 21 KDA POLYPEPTIDE UNDER TRANSLATIONAL CONTROL; HISTAMINE-RELEASING FACTOR; TPT1; P23

E. coli

A DNA sequence encoding the human TPT1 (Met1-Cys172) was expressed with a polyhistidine tag at the N-terminus.

Human

The recombinant human TPT1 consists of 187 amino acids and predicts a molecular mass of 21.4 KDa. It migrates as an approximately 23 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE