Human SUPT5H Recombinant protein (GST tag)

Cat.#: 513341

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Product Information

  • Product Name
    Human SUPT5H Recombinant protein (GST tag)
  • Documents
  • Description
    Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. {PubMed:10075709, PubMed:10199401, PubMed:10393184, PubMed:10421630, PubMed:10454543, PubMed:10757782, PubMed:10912001, PubMed:11112772, PubMed:11553615, PubMed:11809800, PubMed:12653964, PubMed:12718890, PubMed:14701750, PubMed:15136722, PubMed:15380072, PubMed:16214896, PubMed:9450929, PubMed:9514752, PubMed:9857195}.
  • Protein name
    Transcription elongation factor SPT5
  • Protein short names
    SPT5; SPT5H
  • Uniprot ID
    O00267
  • Gene Name
    SUPT5H; SPT5; SPT5H
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human SUPT5H (NP_003160.2) 807-1087 aa was fused with the N-terminal GST tag
  • Protein Species
    Human
  • Activity
    Not tested.
  • Validations

    Recombinant human SUPT5H SDS-PAGE

    Recombinant human SUPT5H SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"