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Product Name
Human SUMO2/SMT3B/SMT3H2 (His tag) recombinant protein
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Description
Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
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Protein name
small ubiquitin-like modifier 2(SUMO2)
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Protein short names
SMT3B; SMT3H2
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Uniprot ID
P61956
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human SUMO2/SMT3B/SMT3H2 Met1-Gly93 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human SUMO2/SMT3B/SMT3H2 (His tag) recombinant protein
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