Human STAT6 (His tag) recombinant protein

Human STAT6 (His tag) recombinant protein

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Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.

signal transducer and activator of transcription 6(STAT6)

P42226

E. coli

A DNA sequence encoding the Human STAT6 Ser627-Ser837 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.