Human SRGN / serglycin (His & Myc Tag) recombinant protein

Human SRGN / serglycin (His & Myc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

SRGN is known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of various hematopoietic cells has a protease-resistant peptide core, and is vital for neutralizing hydrolytic enzymes. SRGN is associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. It is required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. SRGN also plays a role in localizing neutrophil elastase in azurophil granules of neutrophils.

PRG1; SECRETORY GRANULE; GP600; SERGLYCIN; MASTOCYTOMA PROTEOGLYCAN CORE PROTEIN; SERGLYCIN PROTEOGLYCAN; HEMATOPOIETIC PROTEOGLYCAN CORE PROTEIN; SRGN; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE; PROTEOGLYCAN; PLATELET PROTEOGLYCAN CORE PROTEIN; SGC; PROTEOGLYCAN 1; PRG; P.PG; HEMATOPOETIC PROTEOGLYCAN CORE PROTEIN; PPG; SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN; HEMATOPOETIC PROTEOGLYCAN CORE PEPTIDE; SECRETORY GRANULE PROTEOGLYCAN CORE PEPTIDE

Human Cells

A DNA sequence encoding the human SRGN (Met1-Leu158) was fused with the C-terminal polyhistidine-tagged myc at the C-terminus.

Human

The recombinant human SRGN consists of 152 amino acids and predicts a molecular mass of 17.3 KDa. It migrates as an approximately 27 KDa band in SDS-PAGE under reducing conditions.

> 90 % as determined by SDS-PAGE