Human SNAPIN Recombinant protein (His tag)

Human SNAPIN Recombinant protein (His tag)

• DataSheet
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Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. {PubMed:17182842, PubMed:18167355}.

SNARE-associated protein Snapin

BLOC1S7; SNAP25BP; SNAPAP

O95295

SNAPIN; BLOC1S7; SNAP25BP; SNAPAP

E. coli

A DNA sequence encoding the human SNAPIN (NP_036569.1) 1-136 aa was fused with the polyhistidine tag

Human

Not tested.