Human SMARCA5 Recombinant protein (GST tag)

Human SMARCA5 Recombinant protein (GST tag)

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Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. {PubMed:10880450, PubMed:11980720, PubMed:12198550, PubMed:12434153, PubMed:12972596, PubMed:15543136, PubMed:16603771}.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

SNF2H; WCRF135

O60264

SMARCA5; SNF2H; WCRF135

E. coli

A DNA sequence encoding the human SMARCA5 (NP_003592.3) 703-1052 aa was fused with the N-terminal GST tag

Human

Not tested.