Human SH3GLB1 Recombinant protein (GST tag)

Human SH3GLB1 Recombinant protein (GST tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {UniProtKB:Q9JK48, PubMed:11604418, PubMed:15452144, PubMed:17891140, PubMed:20643123, PubMed:21068542}.

Endophilin-B1

KIAA0491

Q9Y371

SH3GLB1; KIAA0491; CGI-61

E. coli

A DNA sequence encoding the human SH3GLB1 (NP_057093.1) 1-365 aa was fused with the N-terminal GST tag

Human

Not tested.