Human SERPINA5/PCI/PLANH3/PROCI (His tag) recombinant protein

Human SERPINA5/PCI/PLANH3/PROCI (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.

serpin family A member 5(SERPINA5)

PCI; PLANH3; PROCI

P05154

Human Cells

A DNA sequence encoding the Human SERPINA5/PCI/PLANH3/PROCI His20-Pro406 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.