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Product Name
Human SENP3 Recombinant protein (His tag)
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Description
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. {PubMed:15743823, PubMed:16608850, PubMed:18259216, PubMed:18946085, PubMed:19015314, PubMed:19680224, PubMed:22872859}.
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Protein name
Sentrin-specific protease 3
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Protein short names
SSP3; SUSP3
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Uniprot ID
Q9H4L4
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Gene Name
SENP3; SSP3; SUSP3
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SENP3 (NP_056485.2) 225-574 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human SENP3 SDS-PAGE
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