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Product Name
Human S100A2 (Fc Tag) recombinant protein
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Description
The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.
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Protein name
Protein S100-A2
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Protein short names
MGC111539; CAN19; RP11-49N14.8; S100A2; EG628324; S100L
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Uniprot ID
P29034
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Gene Name
S100A2; S100L
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Fc/S100A2 is a disulfide-linked homodimer. The reduced monomer consists of 334 amino acids and has a predicted molecular mass of 37.6 kDa. As a result of glycosylation, the apparent molecular mass of rh Fc/S100A2 monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human S100A2 Protein (Fc Tag) SDS-PAGE
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