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Product Name
Human RBPJ Recombinant protein (His tag)
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Description
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). {PubMed:21991380, PubMed:23303788}.
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Protein name
Recombining binding protein suppressor of hairless
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Protein short names
IGKJRB; IGKJRB1; RBPJK; RBPSUH
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Uniprot ID
A0A7P0T9Y9
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Gene Name
RBPJ; IGKJRB; IGKJRB1; RBPJK; RBPSUH
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RBPJ (XP_047271612.1) 158-506 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RBPJ SDS-PAGE
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