Human RALA Recombinant protein (GST tag)

Human RALA Recombinant protein (GST tag)

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Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. {PubMed:18756269, PubMed:19306925, PubMed:20005108}.

Ras-related protein Ral-A

RAL

P11233

RALA; RAL

E. coli

A DNA sequence encoding the human RALA (XP_054214727.1) 1-206 aa was fused with the N-terminal GST tag

Human

Not tested.