Human PROC (His tag) recombinant protein

Human PROC (His tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Vitamin K-Dependent Protein C (PROC) is a serine protease that belongs to the peptidase S1 family. Human PROC is synthesized as a single chain precursor, which is cleaved into a light chain and a heavy chain held together by a disulfide bond. PROC is expressed in plasma and liver. PROC contains one peptidase S1 domain, one Gla (γ-carboxy-glutamate) domain and two EGF-like domains. PROC is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3) and autosomal recessive (THPH4).

protein C, inactivator of coagulation factors Va and VIIIa(PROC)

P04070

Human Cells

A DNA sequence encoding the Human PROC Thr19-Pro461 is expressed with a 6His tag at the C-terminus.

Human

>95% as determined by SDS-PAGE.