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Product Name
Human PRKG1/PRKG1B/PRKGR1A/PRKGR1B (His tag) recombinant protein
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Description
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-signaling pathway, and other processes involved in several aspects of the CNS like axon guidance, hippocampal and cerebellar learning, circadian rhythm, and nociception.
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Protein name
protein kinase, cGMP-dependent, type I(PRKG1)
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Protein short names
PRKG1B; PRKGR1A; PRKGR1B
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Uniprot ID
Q13976-2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human PRKG1/PRKG1B/PRKGR1A/PRKGR1B Gly2-Pro686 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human PRKG1/PRKG1B/PRKGR1A/PRKGR1B (His tag) recombinant protein
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