Human p38 delta/MAPK13 (GST Tag) recombinant protein

Human p38 delta/MAPK13 (GST Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The p38 family of mitogen-activated protein kinases (MAPK) includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6). p38 alpha and p38 beta are widely expressed p38 isoforms that are involved in regulation of cell proliferation, differentiation, development, and response to stress. p38 delta, also known as MAPK13, is a regulator of differentiation-dependent gene expression in keratinocytes, and been as a regulator of surface epithelia differentiation and apoptosis. p38 delta protein is upregulated in Cholangiocarcinoma (CC) relative to hepatocellularcarcinoma (HCC) and to normal biliary tract tissues. p38 delta is important for motility and invasion of CC cells, suggesting that p38 delta may play an important role in CC metastasis. p38 delta is expressed in the epidermis, suggesting a role for p38 delta in regulating differentiation. p38 delta is the major p38 isoform driving suprabasal involucrin gene expression and that p38 delta directly regulates ERK1/2 activity via formation of a p38 delta-ERK1/2 complex. Recent emerging evidence suggests that the p38 stress MAPK pathway may function as a tumor suppressor through regulating Ras-dependent and -independent proliferation, transformation, invasion and cell death by isoform-specific mechanisms. p38 delta has important role in promoting cell proliferation and tumor development in epidermis and may have therapeutic implication for skin cancer.

Mitogen-activated protein kinase 13

MAPK13; MGC99536; P38 DELTA; PRKM13; MAPK-13; SERK4; RP24-313J18.2; P38DELTA; SAPK4; RP1-179N16.4

O15264

MAPK13; PRKM13; SAPK4

Baculovirus-Insect Cells

A DNA sequence encoding the full length of human MAPK13 (O15264) (Met 1-Leu 365) was fused with the GST tag at the N-terminus.

Human

The recombinant human MAPK13/GST chimera consists of 589 amino acids and predicts a molecular mass of 68.4 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE

No Kinase Activity