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Product Name
Human OBFC2B Recombinant protein (GST tag)
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Description
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {PubMed:18449195, PubMed:19605351, PubMed:19683501}.
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Protein name
SOSS complex subunit B1
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Protein short names
OBFC2B; SSB1
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Uniprot ID
Q9BQ15
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Gene Name
NABP2; OBFC2B; SSB1; LP3587
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human NABP2 (XP_054229173.1) 26-236 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human OBFC2B(Full length) SDS-PAGE
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