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Product Name
Human NUDT3 Recombinant protein (His tag)
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Description
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {PubMed:9822604}.
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Protein name
Diphosphoinositol polyphosphate phosphohydrolase 1
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Protein short names
DIPP; DIPP1
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Uniprot ID
O95989
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Gene Name
NUDT3; DIPP; DIPP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human NUDT3 (NP_006694.1) 1-172 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human NUDT3(Full length) SDS-PAGE
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