-
Product Name
Human NPHP1 Recombinant protein (GST tag)
- Documents
-
Description
Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity).
-
Protein name
Nephrocystin-1
-
Protein short names
NPH1
-
Uniprot ID
O15259
-
Gene Name
NPHP1; NPH1
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
1-48 aa encoded by NM_001128179 was inserted into PGEX-4T vector
-
Protein Species
Human
-
Activity
Not tested.
-
Validations
Recombinant human NPHP1 SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"