Human NHLRC1 Recombinant protein (His tag)

Human NHLRC1 Recombinant protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {PubMed:15930137, PubMed:17908927, PubMed:18070875, PubMed:19036738, PubMed:21505799, PubMed:23624058}.

E3 ubiquitin-protein ligase NHLRC1

EPM2B

Q6VVB1

NHLRC1; EPM2B

E. coli

A DNA sequence encoding the human NHLRC1 (NP_940988.2) 86-395 aa was fused with the polyhistidine tag

Human

Not tested.