Human METTL11A (GST Tag) recombinant protein

Cat.#: 503913

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Product Information

  • Product Name
    Human METTL11A (GST Tag) recombinant protein
  • Documents
  • Description
    Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Methylation often occurs on nucleic bases in DNA or amino acids in protein structures. Methytransferase uses a reactive methyl group bound to sulfur in S-adenosyl methionine (SAM) as the methyl donor. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. This methylation occurs on cytosine residues. DNA methylation may be necessary for normal growth from embryonic stages in mammals. Methylation can serve to protect DNA from enzymatic cleavage, since restriction enzymes are unable to bind and recognize externally modified sequences. This is especially useful in bacterial restriction modification systems which use restriction enzymes to cleave foreign DNA while keeping their own DNA protected by methylation. Methylation of amino acids in the formation of proteins leads to more diversity of possible amino acids and therefore more diversity of function. The methylation reaction occurs on nitrogen atoms either on the N terminus or side-chain position of the protein and are usually irreversible.
  • Protein name
    Chromosome 9 open reading frame 32, isoform CRA_a
  • Protein short names
    NRMT; METTL11A; AL033331; RP23-221O14.3; RP11-483H20.8; 2610205E22RIK; AL033332; NTM1A; MGC25577; AD-003; C9ORF32; HOMT1A
  • Uniprot ID
    Q9BV86
  • Gene Name
    C9orf32; hCG_30597
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human METTL11A (NP_054783.2) (Thr 2-Arg 223) was fused with the GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human METTL11A/GST chimera consists of 454 amino acids and has a predicted molecular mass of 52.2 kDa. It migrates as an approxiamtely 48 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 85 % as determined by SDS-PAGE
  • Validations

    Human METTL11A Protein (GST Tag) SDS-PAGE

    Human METTL11A Protein (GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"