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Product Name
Human MAN1B1/UNQ747/PRO1477 (His tag) recombinant protein
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Description
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
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Protein name
mannosidase alpha class 1B member 1(MAN1B1)
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Protein short names
UNQ747; PRO1477
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Uniprot ID
Q9UKM7
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Human MAN1B1/UNQ747/PRO1477 Asp106-Ala699 is expressed with a 6His tag at the C-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human MAN1B1/UNQ747/PRO1477 (His tag) recombinant protein
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