Human LRPPRC Recombinant protein (GST tag)

Human LRPPRC Recombinant protein (GST tag)

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May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {, PubMed:11585913, PubMed:12832482, PubMed:15081402, PubMed:15139850, PubMed:15272088, PubMed:17050673}.

Leucine-rich PPR motif-containing protein, mitochondrial

LRP130

P42704

LRPPRC; LRP130

E. coli

A DNA sequence encoding the human LRPPRC (NP_573566.2) 1014-1394 aa was fused with the N-terminal GST tag

Human

Not tested.